Journal of the American Chemical Society cover

Selective C–F Functionalization of Unactivated Trifluoromethylarenes

Abstract: Fluorinated organic molecules are pervasive within the pharmaceutical and agrochemical industries due to the range of structural and physicochemical properties that fluorine imparts. Currently, the most abundant methods for the synthesis of the aryl–CF2functionality have relied on the deoxyfluorination of ketones and aldehydes using expensive and poorly atom economical reagents. Here, we report a…