Journal of the American Chemical Society cover

Endo and Exo Diels–Alder Adducts: Temperature-Tunable Building Blocks for Chemical Functionalization

Abstract: The development and application of a novel endo furan-protected maleimide building block is reported. The endo isomer undergoes deprotection at temperatures ∼50 °C below the exo derivative. This enables a simple and powerful approach to quantitatively and selectively introduce functional maleimide groups via temperature modulation. Reference: Discekici, E. H.; St. Amant, A. H.; Nguyen,…